Use of Injectable-platelet-rich-fibrin (I-PRF) to Thicken Gingival Phenotype

Bezmialem Vakif University

Status: Completed

Conditions: Blood Clot; Periodontoclasia; Gingiva; Injury; Condition; Gingiva Disorder

Treatments: Other: I-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT03274674

boz002

Details and patient eligibility

About

The main objective of this study is to investigate whether the for individuals with thin gingival thickness who are susceptible to gingival recession, the investigators will use i-PRF with microneedle to increase gingival thickness without the need for surgical procedures

Full description

Due to the thin gingival phenotype, gingival recession is a problem. The investigators aimed to increase the gingival thickness using i-PRF with microneedle without considering surgical procedures, considering the positive effects of platelet concentrations on revascularization and wound healing in individuals with bone defect, fenestration and gingival thickness which are prone to gingival recession .

Enrollment: 29 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Never smokers
• Had no history of systemic disease
• Aged ≥18 years old

Exclusion criteria

• Patients with a history of diabetes mellitus or systemic disease
• Patients who were under any medication that was known to influence periodontal tissues
• Patients with hormonal changes such as pregnancy or lactation
• Toothless individuals
• Patients who were clotting disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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29 participants in 2 patient groups

I-PRF

Experimental group

Description:

Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.I-PRF injected on one side of bilateral thin gingival thickness.Apply once a week and one month after the end of the injections, the patient will be called to the control.

Treatment:

Other: I-PRF

I-PRF and Microneedling

Active Comparator group

Description:

Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.Microneedle application plus I-PRF injected on the other side in patients with bilateral region with thin gingival phenotype.Apply once a week and one month after the end of the injections, the patient will be called to the control.

Treatment:

Other: I-PRF