Use of Intrathecal Analgesia in Appendectomy

Nigde Omer Halisdemir University

Status: Completed

Conditions: Analgesia; Anesthesia

Treatments: Drug: 250 mcg alfentanil; Drug: 25 mcg fentanyl

Study type: Interventional

Funder types: Other

Identifiers

NCT04196946

2013/512

Details and patient eligibility

About

Acute appendicitis which is the most common cause of acute abdominal pain, is an acute inflammation of appendix vermiformis. Appendectomy operations can be performed as laparoscopic and open surgery. Addition of opioids to intrathecal local anesthetics to improve the quality of preoperative analgesia is an increasingly used method in recent years. The aim of this study is to compare bupivacaine-fentanyl and bupivacaine-alfentanil which are used intrathecally to create motor and sensory block. 50 volunteer patients who were diagnosed as appendicitis by laboratory tests and clinical diagnostic methods in general surgery clinic and classified as American Society of Anesthesiologists Classification I-II (ASA Class I-II) aged between 20-60 years scheduled for laparoscopic appendectomy operation, were included in this study. The patients were randomly assigned into two groups, Group I and Group II. Patients received spinal anesthesia with either 10 mg heavy bupivacaine (2 cc)+25 mcg fentanyl (0.5 cc) intrathecally (Group I, n=25) or 10 mg heavy bupivacaine (2 cc)+250 mcg alfentanil (0.5 cc) intrathecally (Group II, n=25).

Enrollment: 50 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals who will undergo laparoscopic appendectomy operation and volunteer to participate in the study were included.

Exclusion criteria

• Individuals who meet the criteria but are not volunteers
• Previously underwent appendectomy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Group I

Experimental group

Description:

25 mcg fentanyl intrathecally

Treatment:

Drug: 25 mcg fentanyl

Group II

Experimental group

Description:

250 mcg alfentanil intrathecally

Treatment:

Drug: 250 mcg alfentanil