Use of Intravitreal Triamcinolone and Retrobulbar Chlorpromazine as Alternatives to the Management of Painful Blind Eye

Hospital Governador Celso Ramos

Status: Completed

Conditions: Blind Painful Eye; Control of Pain Through Drug Injection; Refractory Glaucoma

Treatments: Drug: Triamcinolone; Drug: Chlorpromazine

Study type: Interventional

Funder types: Other

Identifiers

NCT01404364

HGCR-20101

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy of intravitreal triamcinolone and retrobulbar chlorpromazine as alternatives in the management of ocular pain in blind eyes.

Full description

The management of chronic eye pain is a constant challenge to ophthalmology. Treatment varies with the intensity of pain, and topical eye drops and contact lens therapy are effective in many patients. In refractory cases, and without vision, surgical removal of the eye through enucleation is considered classical therapy. As less invasive alternatives we have cyclodestruction and neurolytic drug injection in order to promote analgesia for a prolonged period.

The purpose of this study is to evaluate the efficacy of intravitreal triamcinolone and retrobulbar chlorpromazine as alternatives in the management of This is a prospective study of patients with blind painful eyes not responsive to topical treatment and with no indication for evisceration seen at the Department of Ophthalmology, Hospital Governador Celso Ramos (HGCR) in 2010.

Enrollment: 36 patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients treated in the period at HGCR who wanted to be part of the protocol by signing the consent form

Exclusion criteria

• patients whose follow-up period was less than three months

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

Intravitreal Triamcinolone

Active Comparator group

Description:

Patients with phthisis bulbi received 0,3ml intravitreal triamcinolone injection

Treatment:

Drug: Triamcinolone

Retrobulbar Chlorpromazine

Active Comparator group

Description:

Patients with refractory glaucoma and blind painful eye were submitted to 2,5mL Chlorpromazine retrobulbar injection

Treatment:

Drug: Chlorpromazine