Use of Iv Tramadol and Ketamine for Prevention of Post Spinal Anesthesia Shivering

Liaquat National Hospital & Medical College

Status and phase: Enrolling; Phase 3

Conditions: Shivering, Spinal Anesthesia

Treatments: Drug: Ketamine only; Drug: Tramadol

Study type: Interventional

Funder types: Other

Identifiers

NCT06722742

#882-2023-LNH-ERC

Details and patient eligibility

About

*Ketamine:* Ketamine is a medication that can help reduce shivering by blocking certain nerve signals in the brain. It's like a "nerve blocker" that helps calm down the body's shivering response.

• *Tramadol:* Tramadol is a pain medication that can also help reduce shivering. It works by affecting the brain's temperature regulation centers, which helps to reduce the shivering response.

Full description

Post-spinal shivering is when a patient starts shaking or shivering after receiving spinal anesthesia. This can be uncomfortable and even scary for the patient.

Using ketamine and tramadol to reduce post-spinal shivering can have several benefits, including:

• Reduced discomfort and anxiety for the patient
• Improved patient satisfaction
• Reduced need for additional medications or interventions
• Faster recovery times

Enrollment: 250 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pateint for elective cesarean section
• Age 18 to 40 years
• ASA 1 and 2

Exclusion criteria

• ASA 2 and 3
• Cesarean section requiring general anesthesia
• Hypersensitivity to Ketamine, Tramadol and Opiods
• History of cardiovascular disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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250 participants in 2 patient groups

Group K

Active Comparator group

Description:

Group K receive Inj: ketamine

Treatment:

Drug: Ketamine only

Group T

Active Comparator group

Description:

Group T receive Inj: Tramadol

Treatment:

Drug: Tramadol