Use of Ketamine vs Methohexital for Electroconvulsive Therapy (ECT) on Patient Recovery and Re-orientation Time

University of New Mexico (UNM)

Status: Completed

Conditions: Orientation; Post-anesthesia Recovery

Treatments: Drug: Ketamine; Drug: Methohexital

Study type: Interventional

Funder types: Other

Identifiers

NCT01567852

HRRC#: 11-236

Details and patient eligibility

About

When undergoing ECT treatments, patient recovery time and re-orientation time may be shorter using ketamine for induction than using methohexital.

Full description

ECT treatments are done under general anesthesia, and the induction is commonly done with methohexital. We will study whether using ketamine as an induction agent will result in a faster recovery time and quicker re-orientation time compared to using methohexital.

Enrollment: 20 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients eligible for ECT with a primary mood disorder (bipolar disorder, major depressive disorder) will be eligible to participate in this study. - Patients must have decisional capacity and must be able to consent for this study.

Exclusion criteria

• patients with a primary psychotic disorder (schizophrenia, schizoaffective disorder); patients designated as having an American Society of Anesthesiologist (ASA) Status of greater than 3;
• patients with a known allergic reactions to methohexital , ketamine and succinylcholine;
• patients with current or previous history of aneurysms, intracranial bleeds, or intracranial hypertension;
• patients with uncontrolled severe hypertension.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Ketamine First

Experimental group

Description:

This arm will receive ketamine for induction first, followed by alternating treatments between methohexital and ketamine

Treatment:

Drug: Ketamine

Drug: Methohexital

Methohexital First

Experimental group

Description:

This arm will receive Methohexital first for induction, followed by alternating treatments between ketamine and methohexital.

Treatment:

Drug: Ketamine

Drug: Methohexital