Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients (LAR-CAR-PAR)

Medical University of Silesia

Status: Completed

Conditions: Respiratory Failure; Critical Illness; Sudden Cardiac Arrest; Circulatory Failure; Cardiac Arrest; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT07242027

SUM-SKNIPG-LARCARPAR-ICU-2025

Details and patient eligibility

About

This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults. The study includes all adult patients admitted in 2024 to the ICU Ward B at the Silesian Center for Heart Diseases (SCCS) in Zabrze. Researchers will analyze retrospective clinical and laboratory data from electronic medical records, including lab values collected at ICU admission, patient demographics, diagnoses, and outcomes. The biomarker ratios will be manually calculated in Excel and statistically evaluated. The main goal is to assess whether these ratios are associated with patient survival and to identify predictive cut-off values to support early risk stratification in the ICU setting.

Enrollment: 212 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Admission to ICU in 2024
• Availability of data for lactate, CRP, procalcitonin, and albumin

Exclusion criteria

• Missing outcome data (e.g. unknown survival status)
• Lack of laboratory parameters necessary for ratio calculation

Trial design

212 participants in 2 patient groups

Survivors

Description:

Critically ill adult patients admitted to the ICU who survived hospitalization and were discharged alive.

Non-Survivors

Description:

Critically ill adult patients admitted to the ICU who died during the course of hospitalization.