Use of Laser Assisted New Attachment Procedure and Low Level Laser Therapy for Periodontitis Patients (LANAP LLLT)

Izmir Katip Celebi University

Status

Completed

Conditions

Periodontitis

Treatments

Device: Nd:YAG laser

Study type

Interventional

Funder types

Other

Identifiers

NCT04694222

2017-TDU-DİŞF-0040

Details and patient eligibility

About

In this study, it is evaluated the effects of laser assisted new attachment procedure (LANAP) and low level laser therapy (LLLT) and on clinical, biochemical and radiographic parameters in addition to non-surgical periodontal treatment (NSPT).

Full description

The study was designed as a randomized-controlled, single-blind and parallel design consisting of 80 patients with chronic periodontitis. Study consists of 4 groups, with 20 patients in each group. Group 1 received only NSPT, Group 2 received NSPT+LANAP, Group 3 received NSPT+LLLT, and Group 4 received NSPT+LANAP+LLLT. Clinical measurements of patients and gingival crevicular fluid (GCF) were taken before treatment and after 1 and 3 months. In GCF, interleukin-1beta, interleukin-10 and vascular endothelial growth factor were analyzed. Standard periapical radiographs were taken for radiographic measurements.

In moderate (4-6 mm) and deep pockets (7 mm and above), it was found that all groups treated with laser significantly decrease pocket depth (PD) and clinic attachment level (CAL) compared to Group 1. Group 3 caused significantly less gingival recession than all other groups. There was no statistical difference between the groups in biochemical markers. Radiographic analysis revealed that only Group 2 achieved significant bone filling compared to Group 1.

Bot LANAP and LLLT application in the deep pockets provide an additional contribution to NSPT. It has been found that LLLT administration leads to decrease in PD by creating a minimum recession.

Enrollment

89 patients

Sex

All

Ages

25 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

periodontitis of periodontal stage II, III, or IV with grades B
with at least 12 teeth in the mouth and had ≥4 teeth but not all of them in the same quadrant
with Probing depth of ≥5 mm, Clinical attachment level of ≥4 mm
radiographic evidence of alveolar bone loss

Exclusion criteria

smoking
pregnancy and lactation
using antibiotics in the last 6 months and anti-inflammatory drugs in the last 3rd months,
having the systemic disease and the use of the drug that will affect the periodontal condition, having restoration of the adjacent tooth to be collected gingival crevicular fluid

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

89 participants in 4 patient groups

Control Group

Other group

Description:

scaling and root planning (SRP) was applied.

Treatment:

Device: Nd:YAG laser

LANAP Group

Active Comparator group

Description:

After scaling and polishing, three LANAP stages were performed : In the first stage, Nd:YAG laser was applied. In the second stage, full mouth SRP procedure was performed. In the third stage, Nd:YAG laser was applied again.

Treatment:

Device: Nd:YAG laser

LLLT Group

Active Comparator group

Description:

after SRP Low Level Laser Therapy was performed using Nd:YAG laser.

Treatment:

Device: Nd:YAG laser

LANAP+LLLT Group

Active Comparator group

Description:

after scaling both LANAP and LLLT were applied.