Use of Lidocaine in Endoscopic Submucosal Dissection

Yonsei University

Status: Completed

Conditions: Gastric Neoplasm

Treatments: Drug: Lidocaine 1%; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02543411

4-2014-0933

Details and patient eligibility

About

The primary purpose of this study is to investigate the effects of lidocaine on the total administered dose of fentanyl during sedation for endoscopic mucosal resection.

The secondary purpose of this study is to investigate the effects of lidocaine on pain score related with endoscopic mucosal resection at time of 30 min, 6 hr, and 24 hr after procedure.

Enrollment: 66 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Endoscopic submucosal dissection for the treatments of early gastric neoplasm

Exclusion criteria

1. Allergy to lidocaine
2. Chronic pain
3. Chronic abuse of opioid or NSAID
4. Atrioventricular conductance block
5. Liver dysfunction
6. Renal dysfunction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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66 participants in 2 patient groups, including a placebo group

Lidocaine group

Experimental group

Description:

Administration of lidocaine 1%

Treatment:

Drug: Lidocaine 1%

Control group

Placebo Comparator group

Description:

Administration of normal saline

Treatment:

Drug: Normal saline