Use of Local Analgesia With Epinephrine During Total Hip Arthroplasty (THA)

University Hospital, Clermont-Ferrand

Status and phase: Completed; Phase 2

Conditions: Arthroplasty, Replacement, Hip

Treatments: Drug: ropivacaine, physical serum and adrenalin

Study type: Interventional

Funder types: Other

Identifiers

NCT00980616

CHU-0056

Details and patient eligibility

About

The aim is to determine if the use of infiltration with an adrenalin solution in the operative field of Total Hip Arthroplasty (THA), allays a significant reduction of the cumulated volume of bleeding (pre and post operative) without increasing the per and post operative risks. At the same time, the effect on the post operational pains is evaluated.

Full description

This prospective randomized study compares a population receiving a local anaesthetic (ropivacaine, adrenalin and physiological serum) in the operative field to a population undergoing a standard protocol.

The cumulated volume of bleeding per and post operative are recorded and complete blood count (CBC).

Enrollment: 150 patients

Sex: All

Ages: 50 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary total hip arthroplasty
• Age between 50 and 85

Exclusion criteria

• fracture of the femoral neck
• patients with contraindications for local anaesthesia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 2 patient groups

Ropivacaine, serum, adrenalin

Experimental group

Description:

235 mg of ropivacaine, 5 ml physical serum and 0.5 mg of adrenalin.

Treatment:

Drug: ropivacaine, physical serum and adrenalin

No infiltration

No Intervention group

Description:

B: no infiltration