Use of Local Infiltration Analgesia Following Total Hip Arthroplasty

University of Aarhus

Status and phase: Completed; Phase 4

Conditions: Pain, Postoperative; Pain

Treatments: Drug: ropivacaine and ketorolac; Drug: Ketorolac

Study type: Interventional

Funder types: Other

Identifiers

NCT01344395

2009-016445-25

Details and patient eligibility

About

The primary aim of this study is to evaluate if multiple postoperative administrations with a solution of ropivacaine, ketorolac and epinephrine into the operating field through a catheter would affect morphine consumption. Secondary end-points are pain intensity, side effects and length of stay.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for total hip arthroplasty
• Patients > 18 years of age
• Signed written informed consent
• Spinal anaesthesia

Exclusion criteria

• Allergy towards study drugs
• Rheumatoid arthritis
• Body Mass Index > 35 (severe obesity)
• Pregnancy or nursing women
• Regular opioid use
• Patients who can not read or understand danish

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups

RK-group

Experimental group

Treatment:

Drug: ropivacaine and ketorolac

K-group

Active Comparator group

Treatment:

Drug: Ketorolac