Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study

Centre Hospitalier de Saint-Denis

Status: Completed

Conditions: Glucose-6-Phosphate Dehydrogenase Deficiency; Anti-Bacterial Agents; Sickle Cell Disease; Acute Chest Syndrome; Macrolides

Study type: Observational

Funder types: Other

Identifiers

NCT07037706

0063_REANIMATION

Details and patient eligibility

About

This study looks at whether using macrolide antibiotics is helpful and safe in treating acute chest syndrome, a serious complication in people with sickle cell disease. It reviews past cases from three hospitals where patients were treated in intensive care. The goal is to understand if macrolides make a difference, what germs are involved, how useful lab tests are, and how well patients tolerate these antibiotics.

Enrollment: 250 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient (≥18 years old).
• Diagnosis of acute chest syndrome (ACS).
• Hospitalized in an intensive care unit (ICU).
• Microbiological sampling performed (e.g., multiplex PCR, sputum culture [ECBC], and/or Legionella urinary antigen test).
• Received empiric antibiotic therapy including a macrolide.

Exclusion criteria

• Minor patient (<18 years old).
• Acute chest syndrome not requiring ICU admission.
• Acute chest syndrome without any attempt at microbiological documentation.