Use of Methazolamide to Lower Intraocular Pressure

University of Colorado Denver (CU Denver)

Status and phase: Active, not recruiting; Phase 4

Conditions: Glaucoma, Open-Angle

Treatments: Drug: Methazolamide 25 MG; Drug: Methazolamide 50 MG

Study type: Interventional

Funder types: Other

Identifiers

NCT05498103

22-0721

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.

Enrollment: 30 estimated patients

Sex: All

Ages: 50 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Males and females between 50 and 90 years old
• Current diagnosis of open angle glaucoma (OAG) in both eyes
• Ability to read and write in English

Exclusion criteria

• Glaucoma other than OAG
• Severe or end-stage glaucoma (cup to disc ratio >0.8 or Mean Deviation on Visual Field worse than -12)
• Pregnant or breast-feeding women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

Methazolamide 25 mg

Active Comparator group

Description:

Once a day \[q.d\] in the morning for 1 week, Twice a day \[b.i.d.\] in the morning and evening for 1 week

Treatment:

Drug: Methazolamide 25 MG

Methazolamide 50 mg

Active Comparator group

Description:

Once a day \[q.d\] in the morning for 1 week, Twice a day \[b.i.d.\] in the morning and evening for 1 week

Treatment:

Drug: Methazolamide 50 MG