Use of Methoxyflurane (Penthrox) as an Antalgic in Hospital Trauma (UMATH)

Regional University Hospital Center (CHRU)

Status

Completed

Conditions

Traumatic Injury

Pain

Treatments

Drug: Methoxyflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT03927729

DR190096

2019-A00259-48 (Other Identifier)

Details and patient eligibility

About

Study of traumatized patients treated in emergency departments of Tours, seeking to optimize the management of trauma pain in an inpatient setting, with the opportunity to integrate inhaled methoxyflurane (Penthrox®) into the arsenal analgesics useful in the analgesic protocol of the Reception and Orientation Nurse.

Full description

Intra-hospital, the prevalence of pain is major; this is variable depending on the studies, but permanently above 60%. A study conducted in 2015 in Tours Adult Emergencies showed a prevalence of pain of 66.5% with an average waiting time of 2h28 before receiving an analgesic.

The pain management protocol at the Tours emergency department includes paracetamol for a numerical evaluation scale (EN) < 3 and tramadol for an EN between 4 and 6. But these therapies have a delay of action too long or are given too late. An improvement in the management of pain in emergency is therefore necessary.

Methoxyflurane (Penthrox®) is a volatile fluoridated analgesic; it offers several benefits: fast over a long period, well tolerated, effective and without interference with other drugs. Despite a misuse in the 70s, it has been used for more than 20 years in Australia and New Zealand. It was granted marketing authorization in 2016 and has been marketed in France since 2017.

It should be noted that this analgesic treatment is already adopted in several hospitals in the region and also in the SAMU 37.

A similar study was conducted in Grenoble but on a different population. The investigators plan to highlight the interest of Penthrox® in the management of monotraumatic pains in the Adult Emergencies of Tours with the intention of modifying the antalgic protocol accordingly to the reception of emergencies.

Enrollment

34 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Conscious patient
Age ≥ 18 years
Acute pain of monotraumatic origin
Pain > 4 on a visual numerical scale

Exclusion criteria

State of shock with unstable hemodynamics (PA <90/60)
Suspected or proven trauma to the chest, abdomen or pelvis
Serious head trauma
Consciousness disorder with Glasgow score <15
Patient who has already received analgesics (with the exception of paracetamol)
Patient receiving an intravenous approach for analgesia
Renal or hepatic disorders known
Hypersensitivity to fluoridated anesthetics or history of malignant hyperthermia in the patient or family
Pregnant or nursing woman
Patient under judicial protection
Non communicating patient or with difficulties of understanding