Use of Minocicline in Patients With Stroke

Hospital Universitario Hernando Moncaleano Perdomo

Status and phase: Unknown; Phase 1

Conditions: Brain Ischemia; Stroke; Paralysis

Treatments: Drug: Placebo; Drug: Minocicline

Study type: Interventional

Funder types: Other

Identifiers

NCT01556802

38212050

Details and patient eligibility

About

The investigators will evaluate the National Institute of Health Stroke Scale/Score (NIHSS)in patients with stroke, and then give Minocycline 100mg po every 12 hours or placebo for five days, then perform periodic evaluations to determine the status and degree of neurological sequelae developed.

Enrollment: 134 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• NIHSS scale greater than 5
• Onset of symptoms less than 24 hours
• normal Cranial Tomography(CT)
• CT evidence of cerebral ischemia
• Acceptance of study entry

Exclusion criteria

• Hemorrhagic cerebrovascular disease
• Other neurological diseases
• Concomitant structural damage
• History of neurosurgery
• Known allergy to tetracyclines
• Concomitant infectious diseases requiring antibiotic treatment.
• History of Stroke
• Women pregnant or breast-feeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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134 participants in 2 patient groups, including a placebo group

Minocicline

Experimental group

Description:

minocicline 100mg oral twice a day for 5 days

Treatment:

Drug: Minocicline

Placebo

Placebo Comparator group

Description:

Pills filled with vegetal fiber with similar presentation of the drug. Given one pill oral twice a day for five days

Treatment:

Drug: Placebo