Use of Multiphoton Microscopy in the Diagnosis of Cancer (MPM)

Weill Cornell Medicine (WCM)

Status and phase: Completed; Phase 1

Conditions: Bladder Cancer; Prostate Cancer

Treatments: Other: Multiphoton microscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT00652210

0506007919

Details and patient eligibility

About

Multiphoton microscopy (MPM) has been shown to be able to image tissue at a cellular level. Our project will initially evaluated the ability of MPM imaging to distinguish normal bladder urothelium from atypical and malignant urothelium in the ex vivo setting. After development of sufficient criteria, we plan to develop an endoscopic bladder probe that will provide a non-invasive means to image the interior of the bladder at the cellular level, which would provide direct evidence of the presence of tumor without a biopsy. After exhibiting usefulness of MPM imaging for bladder cancer, we will look at other organs beginning with the colon.

Full description

Same as above

Enrollment: 344 patients

Sex: All

Ages: 21 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Anyone who presents with bladder and/or prostate cancer

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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344 participants in 1 patient group

MPM

Experimental group

Description:

Subject tissue was reviewed using multiphoton microscopy

Treatment:

Other: Multiphoton microscopy