Use of Normal Saline With or Without Dextrose During Induction of Labor in Nulliparous (DEXTRONS)

U

Université de Sherbrooke

Status

Completed

Conditions

Delivery Uterine

Treatments

Other: 5% dextrose
Other: normal saline

Study type

Interventional

Funder types

Other

Identifiers

NCT02655783
12-143

Details and patient eligibility

About

The objective of this study is to compare the effects of use of normal saline (250 cc / h), with or without dextrose supplement, on the evolution of labor in nulliparous.

Full description

There is some controversy regarding intravenous hydration of patients during labor. While the use of a fast flow of hydration appears to be recognized beneficial, the addition of glucose is less well accepted. However studies on exercise physiology clearly demonstrates improved performance of skeletal muscle by increased hydration and carbohydrate replacement during prolonged exercise. This situation is similar to the condition of the uterus in labor especially since it is now established that glucose represents its principal source of energy. However, the effect of an additional carbohydrate intake on the evolution of labor has not been extensively studied until now, and there are several schools of thought on this subject. While some studies show that such glucose addition could reduce the total duration of labor as well as its second stage, others claim that this glucose supplement offers no benefit and may even be harmful to the fetus. It therefore seems imperative to conduct a study to compare the use of hydration with normal saline with or without dextrose during labor, as recommended in current flow (250 cc / h). To our knowledge, this has never been done.

Enrollment

200 patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • nulliparous woman
  • monofetal pregnancy
  • delivery at term
  • elective induction
  • favorable cervix (Bishop score of at least 6)
  • cephalic presentation

Exclusion criteria

  • diabetes
  • preeclampsia
  • maternal heart disease

Trial design

200 participants in 2 patient groups

control
Active Comparator group
Description:
normal saline, 250 ml/h, until expulsion of placental
Treatment:
Other: normal saline
intervention
Experimental group
Description:
normal saline + 5% dextrose, 250 ml/h, until expulsion of placental
Treatment:
Other: normal saline
Other: 5% dextrose

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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