Use of NPSP558 in the Treatment of Hypoparathyroidism (REPLACE)

Shire

Status and phase

Completed

Phase 3

Conditions

Hypoparathyroidism

Treatments

Drug: Placebo

Drug: NPSP558

Study type

Interventional

Funder types

Industry

Identifiers

NCT00732615

CL1-11-040

2008-005063-34 (EudraCT Number)

Details and patient eligibility

About

Use of PTH (1-84) a recombinant hormone in escalating doses for the treatment of adults with hypoparathyroidism. The use of PTH should result in a decrease of calcium and vitamin D supplements.

Full description

Patients with a history of hypoparathyroidism will be randomized to receive placebo or study drug for 24 weeks, which will be injected daily in either thigh. During that time they will be monitored for safety (specifically, calcium levels in the blood and urine). In addition, the patients' intake of Vitamin D and calcium will be measured.

Enrollment

124 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Patients who meet all of the following inclusion criteria can be enrolled and potentially randomized into this study:

Adult males or females 18 to 85 years of age (prior to screening)
History of hypoparathyroidism for ≥ 18 months
Requirement for vitamin D metabolite/analog therapy with calcitriol ≥0.25 μg per day or alphacalcidol ≥0.50 μg per day prior to randomization. Requirement for supplemental oral calcium treatment ≥ 1000 mg per day over and above normal dietary calcium intake
Serum thyroid function tests within normal laboratory limits at screening
Serum magnesium levels within laboratory normal limits
Serum 25-hydroxyvitamin D [25(OH)D] level ≤ 1.5-fold the laboratory upper limit of normal
Creatinine clearance > 30 mL/min on two separate measurements OR creatinine clearance > 60 mL/min AND serum creatinine < 1.5 mg/dL
With regard to female patients: women who are postmenopausal and women who are surgically sterilized can be enrolled. Women of childbearing potential must have a negative pregnancy test at Randomization and be willing to use two medically acceptable methods of contraception for the duration of the study.

Exclusion Criteria

Patients who have any of the following during the screening visit are not eligible for enrollment in this study:

Known history of hypoparathyroidism resulting from an activating mutation in the CaSR gene or impaired responsiveness to PTH (pseudohypoparathyroidism)
Any disease that might affect calcium metabolism or calcium-phosphate homeostasis other than hypoparathyroidism, such as active hyperthyroidism, Paget's disease, insulin dependent diabetes mellitus (IDDM) or poorly controlled Type II diabetes mellitus (HbA1C > 8%), severe and chronic cardiac, liver or renal disease, Cushing's syndrome, neuromuscular disease such as rheumatoid arthritis, myeloma, pancreatitis, malnutrition, rickets, recent prolonged immobility, active malignancy, primary or secondary hyperparathyroidism, a history of parathyroid carcinoma, hypopituitarism, acromegaly, or multiple endocrine neoplasia types I and II
Patients with a history of thyroid cancer must be documented to be disease-free for a period of at least 5 years
Patients dependent on regular parenteral calcium infusions (eg calcium gluconate) to maintain calcium homeostasis
Patients that have undergone gastric resection or have active peptic ulcer disease requiring medical therapy
Use of prohibited medications such as loop and thiazide diuretics, raloxifene hydrochloride, lithium, estrogens and progestins for hormone replacement therapy,methotrexate, or systemic corticosteroids within respective prohibited periods
Previous treatment with PTH-like drugs, including PTH(1-84), PTH(1-34) or other N-terminal fragments or analogs of PTH or PTH-related protein within 6 months prior to screening
Other drugs known to influence calcium and bone metabolism, such as calcitonin, fluoride tablets, or cinacalcet hydrochloride within the prohibited period
Use of oral bisphosphonates within the previous 6 months or IV bisphosphonate preparations within the previous 12 months prior to screening
Seizure disorder/epilepsy with a history of a seizure within the previous 6 months prior to screening
Presence of open epiphyses
Irradiation (radiotherapy) to the skeleton within 5 years
Serum 25-hydroxyvitamin D levels greater than 1.5-fold the laboratory upper limit of normal
Participation in any other investigational trial in which receipt of investigational drug or device occurred within 6 months prior to screening for this study
Pregnant or lactating women
History of diagnosed drug or alcohol dependence within the previous 3 years
Clinical history of renal calculi within the past 12 months
History of gout
Disease processes that may adversely affect gastrointestinal absorption, including but not limited to short bowel syndrome, bowel resection, tropical sprue, celiac disease, ulcerative colitis, and Crohn's disease
Chronic/severe cardiac disease including but not limited to cardiac insufficiency, arrhythmias, bradycardia (resting heart rate < 60 beats/minute), or hypotension (systolic and diastolic blood pressures < 100 and 60 mmHg, respectively)
History of cerebrovascular accident (CVA).