Use of Peppermint Oil During Screening Colonoscopy to Improve Visibility

Mayo Clinic

Status: Completed

Conditions: Enhancement of the ADR During Colonoscopy

Treatments: Other: Peppermint Oil; Other: Distilled water

Study type: Interventional

Funder types: Other

Identifiers

NCT03286764

14-006242

Details and patient eligibility

About

The investigators hypothesize that spraying peppermint oil containing L-menthol onto the colonic mucosa during colonoscopy will relax smooth muscle allowing better colonic visualization.

Enrollment: 48 patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Screening colonoscopy
• Age 50 years and older
• Able to give consent

Exclusion criteria

• No consent obtained or adult lacking capacity to consent
• Do not reach cecum on colonoscopy
• Renal impairment (defined as CrCl <30 ml/min)
• Allergy to study peppermint oil solution
• History of colon resection
• Inflammatory bowel disease
• Known colorectal neoplasia
• Non-correctable coagulopathy
• Pregnancy or lactating
• Prisoners

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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48 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Distilled water spray as a placebo during Colonoscopy

Treatment:

Other: Distilled water

Peppermint Oil

Experimental group

Description:

Peppermint Oil spray during Colonoscopy

Treatment:

Other: Peppermint Oil