Use of Platelet-rich Plasma (PRP) Therapy in Patients With Brittle Nail Syndrome

Weill Cornell Medicine (WCM)

Status and phase: Completed; Phase 4

Conditions: Nail Diseases

Treatments: Device: Platelet-poor plasma; Device: Platelet-rich plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT04941807

20-07022437

Details and patient eligibility

About

The purpose of this study is to assess the efficacy and safety of platelet-rich plasma therapy for brittle nail syndrome

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have been diagnosed with brittle nails
• Must understand and voluntarily sign an informed consent form
• Must be male or female and aged 18-95 years at time of consent
• Must be able to adhere to the study visit schedule and other protocol requirements
• A nail clipping with histopathology that is negative for the presence of dermatophyte infection
• Patient must present with at least a score of 2 on the PGA scale.

Exclusion criteria

• Inability of the patient to provide written informed consent for any reason.

  • Subject has psoriasis, lichen planus, dermatophyte infection or other confounding abnormalities that are severe enough to result in a clinically abnormal fingernail
  • Use of any medication within 90 days prior to start of study
  • Inability to abstain for nail polishes, nail gels during the study period
  • Subject is pregnant or planning pregnancy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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11 participants in 2 patient groups, including a placebo group

Platelet-rich plasma

Experimental group

Description:

The proximal nail fold is cleansed with alcohol and platelet-rich plasma obtained from the patient is injected using a 1ml syringe and 30g needle, 0.1-0.2 ml of platelet-rich plasma is injected into 8 proximal nail folds.

Treatment:

Device: Platelet-rich plasma

Platelet-poor plasma

Placebo Comparator group

Description:

The proximal nail fold is cleansed with alcohol and platelet-poor plasma obtained from the patient is injected using a 1ml syringe and 30g needle, 0.1-0.2 ml of platelet-poor plasma is injected into 2 proximal nail folds.

Treatment:

Device: Platelet-poor plasma