Use of Preanesthetic Dexmedetomidine in Elderly, Treated-hypertensive Patients

D

DongGuk University

Status and phase

Completed
Phase 4

Conditions

Perioperative Care

Treatments

Drug: Dexmedetomidine
Drug: Normal Saline

Study type

Interventional

Funder types

Other

Identifiers

NCT02768610
110757-201602-HR-03-03

Details and patient eligibility

About

Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and analgesic properties. This study was designed to evaluate the inhibitory effects of preoperative 0.5 μg/kg dexmedetomidine on hemodynamic responses caused by endotracheal intubation in elderly patients being treated for hypertension. Methods: Forty elderly (≥ 65 years) treated-hypertensive patients of American Society of Anesthesiologists physical status II undergoing elective noncardiac surgery were randomly and assigned to two groups. Group C received normal saline and group D received 0.5 μg/kg dexmedetomidine intravenously over 10 min just before endotracheal intubation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were recorded preoperatively at ward, immediately after study drug administration, and at 1, 3, and 5 minutes after endotracheal intubation.

Enrollment

2 patients

Sex

All

Ages

65 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • American Society of Anesthesiologists physical status II
  • Scheduled for elective noncardiac surgery
  • Being treated with anti-hypertensive medication

Exclusion criteria

  • Endotracheal intubation attempted more than twice
  • Morbidly obese (BMI > 35 kg/m2)

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

2 participants in 2 patient groups, including a placebo group

dexmedetomidine
Experimental group
Description:
0.5 mcg/kg dexmedetomidine is administered before endotracheal intubation for 10 minutes
Treatment:
Drug: Dexmedetomidine
Normal Saline
Placebo Comparator group
Treatment:
Drug: Normal Saline

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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