Use of Preanesthetic Dexmedetomidine in Elderly, Treated-hypertensive Patients

DongGuk University

Status and phase: Completed; Phase 4

Conditions: Perioperative Care

Treatments: Drug: Dexmedetomidine; Drug: Normal Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02768610

110757-201602-HR-03-03

Details and patient eligibility

About

Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and analgesic properties. This study was designed to evaluate the inhibitory effects of preoperative 0.5 μg/kg dexmedetomidine on hemodynamic responses caused by endotracheal intubation in elderly patients being treated for hypertension.

Methods: Forty elderly (≥ 65 years) treated-hypertensive patients of American Society of Anesthesiologists physical status II undergoing elective noncardiac surgery were randomly and assigned to two groups. Group C received normal saline and group D received 0.5 μg/kg dexmedetomidine intravenously over 10 min just before endotracheal intubation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were recorded preoperatively at ward, immediately after study drug administration, and at 1, 3, and 5 minutes after endotracheal intubation.

Enrollment: 2 patients

Sex: All

Ages: 65 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status II
• Scheduled for elective noncardiac surgery
• Being treated with anti-hypertensive medication

Exclusion criteria

• Endotracheal intubation attempted more than twice
• Morbidly obese (BMI > 35 kg/m2)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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2 participants in 2 patient groups, including a placebo group

dexmedetomidine

Experimental group

Description:

0.5 mcg/kg dexmedetomidine is administered before endotracheal intubation for 10 minutes

Treatment:

Drug: Dexmedetomidine

Normal Saline

Placebo Comparator group

Treatment:

Drug: Normal Saline