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Use of Procalcitonin in the Diagnosis of Pleural Effusion

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National Taiwan University

Status

Unknown

Conditions

Pleural Effusion

Study type

Observational

Funder types

Other

Identifiers

NCT00172835
9461700208

Details and patient eligibility

About

Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections. PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected. The mechanism proposed for PCT production after inflammation and its role are still not completely known. It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines. It binds to polysaccharides in pathogens, activating the classical complement pathway. The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Clinical diagnosis of pleural effusion
  • Pleural effusion proved by chest sonography

Exclusion criteria

  • Conditions for which thoracentesis are contraindicated
  • Pregnancy

Trial contacts and locations

1

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Central trial contact

Po-Ren Hsueh, MD

Data sourced from clinicaltrials.gov

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