Use of Sodium Bicarbonate As Prophylaxis for Kidney Damage in Patients with Heatstroke

Hospital General de Mexicali

Status: Enrolling

Conditions: Heat Stroke; Acute Kidney Injury Due to Hypovolaemia; Acute Kidney Injury

Treatments: Drug: Sodium bicarbonate; Other: No intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT06622525

HGMexicali

Details and patient eligibility

About

This study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke. It is based on previous studies showing that bicarbonate infusion reduces renal failure in similar contexts. The intervention will be conducted at the General Hospital of Mexicali during the summer, targeting the prevention of renal failure and reducing the necessity for renal replacement therapy.

Full description

The present study protocol explores the possibility of preventing the need for renal replacement therapy in patients who develop rhabdomyolysis secondary to heatstroke. This is based on previous studies that have used bicarbonate infusion in the context of rhabdomyolysis secondary to compartment syndrome, finding a lower incidence of renal failure. Due to the aforementioned, we propose to carry out a similar intervention at the General Hospital of Mexicali, where there is a significant incidence of heatstroke during the summer months. The aim is to determine whether this intervention is useful in preventing the development of renal failure and the requirement for renal replacement therapy.

Enrollment: 1 estimated patient

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Admitted to the General Hospital of Mexicali with the diagnosis of heat stroke.
• Meeting the operational definition (exposure to heat, body temperature at admission greater than 40 degrees Celsius).
• CPK level greater than 1000 U/L.
• Having informed consent from the patient or the legally responsible adult.

Exclusion criteria

• Exclusion of the heat stroke diagnosis during their evaluation.
• Lack of serum creatinine levels at the time of admission to the protocol.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1 participants in 2 patient groups

Intervention Group

Experimental group

Description:

This group will receive 100 mEq of sodium bicarbonate diluted in one liter of saline solution, administered at a rate of 100 ml/h, with the goal of maintaining a urinary pH greater than 6.5.

Treatment:

Drug: Sodium bicarbonate

Control Group

Active Comparator group

Description:

This group will be manage with the usual care that is given to patients with heat stroke in this hospital.

Treatment:

Other: No intervention