Use of Subanesthetic Dose Propofol Before Extubation

Yuzuncu Yil University

Status: Completed

Conditions: Emergence Agitation; Patient Satisfaction; Rhinoplasty

Treatments: Drug: Propofol (Sub-Anesthetic Dose); Other: Normal Saline (Placebo)

Study type: Interventional

Funder types: Other

Identifiers

NCT07276633

Subanesthetic Dose of Propofol

Details and patient eligibility

About

This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty. Emergence agitation refers to restlessness and confusion during early recovery from anesthesia, which may affect patient safety and surgical conditions. The study evaluates agitation levels, recovery characteristics, and patient-reported comfort following propofol administration compared with standard care.

Full description

This study aims to evaluate whether administering a sub-anesthetic dose of propofol before extubation can reduce emergence agitation, enhance recovery characteristics, and improve patient comfort in adults undergoing rhinoplasty surgery. Emergence agitation is a common phenomenon during early recovery from general anesthesia and can involve restlessness, disorientation, and involuntary movements, potentially affecting patient safety and surgical outcomes. The study uses a randomized controlled design to compare peri-extubation responses between patients receiving low-dose propofol and those receiving standard care.

Enrollment: 80 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages 18-65 years
• Patients scheduled for rhinoplasty surgery
• ASA physical status I-II
• No respiratory tract infection
• Provided written informed consent

Exclusion criteria

• Refusal to participate
• Presence of any respiratory tract infection
• Younger than 18 or older than 65
• ASA III-IV
• Known allergy to study medications
• Predicted difficult intubation

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Propofol Group

Active Comparator group

Description:

Sub-anesthetic dose of propofol (0.5 mg/kg) administered 10 minutes before extubation.

Treatment:

Other: Normal Saline (Placebo)

Control Group

Sham Comparator group

Description:

Normal saline administered 10 minutes before extubation.

Treatment:

Drug: Propofol (Sub-Anesthetic Dose)