Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)

University of Sao Paulo

Status and phase: Completed; Phase 3

Conditions: Paraparesis Spastic Tropical

Treatments: Drug: Valproic acid; Drug: valproid acid plus corticosteroids; Drug: costicosteroids

Study type: Interventional

Funder types: Other

Identifiers

NCT00681980

278

Details and patient eligibility

About

Is the valproic acid efficacy to treat TSP/HAM

Enrollment: 60 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HTLV-1; TSP/HAM fulfill criteria

Exclusion criteria

• Age <18 years

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

A, 2, III

Experimental group

Description:

Patients with side effects to corticosteroids

Treatment:

Drug: Valproic acid

B

Experimental group

Description:

patient with corticosteroids

Treatment:

Drug: costicosteroids

3

Experimental group

Description:

Valproic acid and corticosteroids

Treatment:

Drug: valproid acid plus corticosteroids