Use of Virtual Reality Goggles During Chemotherapy Infusion to Reduce Anxiety-Related Symptoms

OHSU Knight Cancer Institute

Status: Completed

Conditions: Malignant Thoracic Neoplasm; Malignant Head and Neck Neoplasm; Malignant Breast Neoplasm; Malignant Solid Neoplasm; Hematopoietic and Lymphoid System Neoplasm

Treatments: Behavioral: Telephone-Based Intervention; Other: Questionnaire Administration; Other: Virtual Technology Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT05793957

NCI-2023-01954 (Registry Identifier)

STUDY00025461 (Other Identifier)

Details and patient eligibility

About

This clinical trial evaluates the use of virtual reality (VR) goggles during chemotherapy infusion to reduce anxiety-related symptoms in patients with head and neck, thoracic, hematologic, and breast cancers. Virtual reality headsets provide the ability for users to explore a simulated, three-dimensional environment with which users can interact. In virtual reality users can play interactive games, enjoy relaxing experiences, and watch immersive videos. The use of VR goggles may help with anxiety management during chemotherapy infusion.

Full description

PRIMARY OBJECTIVE:

I. To evaluate the effectiveness of VR therapy in reducing severity of anxiety symptoms during chemotherapy infusion, compared to participants utilizing a smartphone as a control.

SECONDARY OBJECTIVES:

I. To evaluate whether there is a short-term effect of VR use in anxiety levels.

II. To assess participant satisfaction with their chemotherapy infusion experience in the control and treatment groups.

EXPLORATORY OBJECTIVE:

I. To assess participants' reported adverse effects associated with VR headset use.

OUTLINE: Patients are randomized to 1 of 2 groups.

GROUP 1: Patients use VR during chemotherapy infusion on study.

GROUP 2: Patients use smartphone during chemotherapy infusion on study.

Enrollment: 50 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• English speaking: Ability to interact with virtual reality content may be impacted by inability to understand English; moreover, paper questionnaires will only be provided in English.
• Older than 18 years of age, and younger than 89 years of age. All sexes/gender identities and members of all races and ethnic groups will be included.
• Planned to receive chemotherapy infusion for head and neck, breast, thoracic, and hematologic cancers at the Oregon Health & Science University (OHSU) South Waterfront Center for Health & Healing building 2 (there are no restrictions related to prior chemotherapy infusions or other cancer treatments).
• Chemotherapy treatment lasting at least 10 minutes.
• Ability to understand and willingness to sign a written informed consent document.

Exclusion criteria

• Social or psychiatric conditions that may interfere with compliance.
• Reconstruction, incisions, wounds, wound care, or injury that impact the ability to place on the VR headset. This would limit the ability to utilize the VR headset.
• History of seizure or epilepsy.
• History of vertigo or persistent dizziness.
• Use of cardiac pacemaker, requirement for hearing aid on at all times, or have defibrillators.
• Children.
• Pregnant women.
• Decisionally impaired adults.
• Prisoners.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Group 1 (VR)

Experimental group

Description:

Patients use VR during chemotherapy infusion on study.

Treatment:

Other: Virtual Technology Intervention

Other: Questionnaire Administration

Group 2 (Smartphone)

Active Comparator group

Description:

Patients use smartphone during chemotherapy infusion on study.

Treatment:

Behavioral: Telephone-Based Intervention

Other: Questionnaire Administration