Usefulness of Cephalometry in the Second and Third Trimester of Pregnancy in the Diagnosis of Fetal Microretrognathia

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University Hospital Center (CHU)

Status

Completed

Conditions

Pierre Robin Sequence

Treatments

Other: Fetal cephalometry

Study type

Observational

Funder types

Other

Identifiers

NCT04422067
RECHMPL20_0295

Details and patient eligibility

About

Congenital retrognathia, with or without Pierre Robin Sequence (PRS), is a rare anomaly which can be associated with chromosomal abnormalities. Respiratory and feeding consequences can be present at birth. After birth, the diagnosis of retrognathia is based on the clinical examination. Cephalometry can be used to complete the diagnosis. Several authors have proposed the use of objective quantitative ultrasound parameters for the antenatal screening of PRS. In our study, the investigators evaluated fetal cephalometry. The aim First, the investigators studied the inter- and intra-observer reproducibility of cephalometry. Second, the investigators established reference values for antenatal cephalometry in normal fetuses. Third, the investigators compared the diagnostic performance of cephalometry and the other angles described in the literature for the diagnosis of retrognathia.

Enrollment

68 patients

Sex

All

Ages

18 to 44 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Pregnant patient (Aged >18years old)
  • with one or more fetuses suffering from a microretrognathia
  • diagnosed prenatally
  • integrated into a Pierre Robin Sequence

Exclusion criteria

  • Uncvertain diagnosis
  • Absence of 3D rendering volume

Trial design

68 participants in 2 patient groups

Case group (Retrognatism)
Description:
All pregnant patients with one or more fetuses suffering from a microretrognathia, diagnosed prenatally and integrated into a Pierre Robin Sequence, were included. All cases were confirmed postnatally, either by a pediatric examination or by a fetopathological examination in the case of a medical termination of the pregnancy. We had 21 cases.
Treatment:
Other: Fetal cephalometry
Control group
Description:
47 pregnant patients with fetus without facial abnormalities
Treatment:
Other: Fetal cephalometry

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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