Usefulness of Chromoendoscopy for the Early Detection of Colorectal Cancer Associated With Inflammatory Bowel Disease (CE)

Hospital Clinic of Barcelona

Status: Completed

Conditions: Inflammatory Bowel Disease; Colorectal Cancer

Treatments: Procedure: Chromoendoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT02543762

3-Ceron

Details and patient eligibility

About

To assess the feasibility and effectiveness of a program in L-IBD patients using CE targeted biopsies

Full description

We aim to know the prevalence and incidence of dysplasia and colitis-associated colorectal cancer in patients with longstanding colonic inflammatory bowel disease (N-IBD), in Spain and the usefulness of advanced endoscopy (chromoendoscopy) for the diagnosis and endoscopic differential diagnosis of N-IBD.

Enrollment: 350 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of UC or colitis EC corroborated by clinical and histology
• involvement of at least one third of the colon in patients with CD
• involvement proximal to the rectum in patients with UC
• Duration of disease > 10 years
• No clinical activity:
• May Score <6
• CDEIS <3.5

Exclusion criteria

• Personal history of CRC
• colectomy
• coagulopathy
• refusal to participate in the study
• known allergy to indigo carmine
• colonoscopy in the last 6 months

Trial design

350 participants in 1 patient group

Inflammatory Bowel Disease

Description:

Inflammatory bowel disease (IBD) is comprised of two major disorders: ulcerative colitis and Crohn disease. Ulcerative colitis is a chronic inflammatory condition characterized by relapsing and remitting episodes of inflammation limited to the mucosal layer of the colon. It almost invariably involves the rectum and typically extends in a proximal and continuous fashion to involve other portions of the colon. Crohn disease is characterized by transmural inflammation and by skip lesions. The transmural inflammatory nature of Crohn disease may lead to fibrosis and strictures, and to obstructive clinical presentations that are not typically seen in ulcerative colitis. More commonly, the transmural inflammation results in sinus tracts, giving rise to microperforations and fistulae. Crohn disease may involve the entire gastrointestinal tract from mouth to perianal área patients with long-standing inflammatory bowel disease are prone to the development of colorectal cancer

Treatment:

Procedure: Chromoendoscopy