Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis

Karolinska University Hospital

Status: Unknown

Conditions: Lymphocytic Colitis; Collagenous Colitis; Chronic Diarrhoea

Treatments: Procedure: Colonoscopy with Indigo-Carmine Chromoendoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT01504048

PTS-02

Details and patient eligibility

About

The purpose of this study is to determine whether chromoendoscopy using Indigo-Carmine dye spray is useful in diagnosing microscopic colitis among patients undergoing colonoscopy due to chronic watery diarrhea.

Full description

Microscopic colitis is a common disease found in 10% to 20% of cases having chronic watery diarrhea. Obvious endoscopically identifiable changes of the mucosal surface are usually absent, thus diagnosing microscopic colitis relies on multiple biopsy sampling from all segments of the colon. Chromoendoscopy using indigo-carmine dye spray might, however, unravel mucosal changes in microscopic colitis (Suzuki 2011).

The aim of this study is to investigate if chromoendoscopy using Indigo-Carmine 0.2-0.5% in patients with chronic watery diarrhea is useful in diagnosing microscopic colitis.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with chronic non-bloody diarrhea for at least one month

Exclusion criteria

• Patients who decline to participate
• Unable to give informed consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

150 participants in 1 patient group

Chromoendoscopy

Experimental group

Treatment:

Procedure: Colonoscopy with Indigo-Carmine Chromoendoscopy