Usefulness of Interferon-gamma Release Assay in Diagnosing Pulmonary Nodules

Seoul National University

Status: Unknown

Conditions: Solitary Pulmonary Nodule

Study type: Observational

Funder types: Other

Identifiers

NCT01149187

SeoulNUH-IGRA-01

Details and patient eligibility

About

Among the causes of the solitary pulmonary nodule (SPN), benign causes including tuberculosis was noted on 15 to 60 percents in various studies.

Although the characteristics of chest imaging is helpful in diagnosis and percutaneous needle biopsy for pulmonary nodule has been represented high diagnostic yield in many reports, but still surgical biopsy has been needed in definite diagnosis of pulmonary nodules in many cases.

The aim of this study is to evaluate the usefulness of interferon-gamma release assay in addition to the percutaneous needle biopsy, in diagnosis of pulmonary nodules.

Full description

Among the patients who failed to diagnosis by percutaneous needle biopsy and needed to have Surgical biopsy, thirty percents of the patients were diagnosed as benign nodules and about six percents were diagnosed as tuberculosis in Seoul National University Hospital during 2007-2008.

The investigators want to know whether conducting an interferon-gamma release assay in addition to percutaneous needle biopsy is helpful in diagnosis of lung nodules.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age> 18 years
• in patients with solitary pulmonary nodule
• who had percutaneous needle biopsy for diagnosis of lung nodule

Exclusion criteria

• patients who do not agree the study enrollment

Trial design

400 participants in 1 patient group

IGRA in solitary pulmonary nodules

Description:

Inpatients who undergo percutaneous needle biopsy for diagnosis of pulmonary nodules in Seoul National University hospital for six months are going to be included. Patients who are not tolerable for PCNB or do not agree the enrollment of study will be excluded.