Usefulness of Multi-parametric, Quantitative MR Imaging for Staging of Hepatic Fibrosis in the Patients With Chronic Hepatitis

Yonsei University

Status: Unknown

Conditions: Liver Fibrosis

Study type: Observational

Funder types: Other

Identifiers

NCT01981421

4-2011-0193

Details and patient eligibility

About

Liver fibrosis has been considered as irreversible change. However, recent study showed that early stage liver fibrosis could be reversible and a lot of new drugs are now developing or developed including anti-viral treatment. Liver biopsy is considered as golden standard for the evaluation of liver fibrosis. But biopsy specimen through biopsy only consists of 1/50000 of the whole liver and heterogeneity of liver fibrosis, accurate diagnosis of liver fibrosis is still challenging. Furthermore, its invasive nature, repeated biopsy is practically almost impossible. Hence, non-invasive diagnosis of liver fibrosis is important. In this study we hypothesized that multi-parametric MR imaging including MR elastography, conventional DWI, and IVIM can predict changes of liver stiffness after anti-viral therapy in patients with chronic liver disease. We will enroll 60 biopsy-proven patients and perform multi-parametric MR imaging at the enrollment and one year later to evaluate changes in quantitative values in MR.

Enrollment: 60 estimated patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who had chronic hepatitis
• Patients who underwent liver biopsy within 6 months
• Patients older than 18 years old

Exclusion criteria

• patient who had pregnancy
• patient 18 or below 18 years old

Trial design

60 participants in 1 patient group

Liver fibrosis

Description:

patients who had chronic liver disease