Uses of Immunosuppression Therapy in Patients With Liver Transplantation

Chang Gung Medical Foundation

Status: Completed

Conditions: Evidence of Liver Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT01834690

102-0582C

Details and patient eligibility

About

Conventionally, the outcome of liver transplantation is usually reported in terms of graft and patient survival, medical and surgical complications, but lack of health-related quality of life (HRQOL) that might be associated with immunosuppression complications (e.g., diabetes, hypertension, dyslipidemia, obesity, metabolic syndrome, cardiovascular disease, renal dysfunction, osteoporosis, and de novo malignancy), disease recurrence, and rejections after transplantation.

Full description

Specific aims are proposed to achieve in this study:

1. To compare graft and patient survival rate, incidence of treatment-related adverse effects between different patterns of immunosuppression combination among patients received post-liver transplant care in Kaohsiung Chang Gung Memorial Hospital (KCGMH), Taiwan.
2. To quantify the long-term health impacts of immunosuppressive regimens on quality-adjusted life expectancy (QALE), the loss-of-QALE relating to immunosuppression therapy, and types of transplantation.

Enrollment: 314 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Aim 1:

Inclusion Criteria:

• age at liver transplantation is at least 20 years

Aim 2:

Inclusion Criteria:

• age at liver transplantation is at least 20 years

Exclusion Criteria:

• deceased patient
• cannot obtain inform consent
• age <20 years

Trial design

314 participants in 1 patient group

liver transplantation recipients

Description:

adult liver transplantation recipients (\>=20 years at the date of surgery)