Using a Mouthwash Containing Propolis, Clove Oil and Chlorhexidine to Improve the Caries Risk of High Risk Patients

Moataz Gamal Ali Abdul-Maksoud Konsouh

Status: Completed

Conditions: Risk Reduction; Caries, Dental

Treatments: Other: Chlorhexidine mouthwash; Other: Chlorhexidine, Propolis and Clove Oil mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT03553628

oper252215

Details and patient eligibility

About

This study is conducted to determine if using a mouthwash containing propolis, clove oil and chlorhexidine will improve the caries risk of high risk patients in comparison to using a mouthwash containing chlorhexidine only.

Full description

A total of 64 patients will be assigned in this study. Patients will be randomly divided into two groups according to type of mouthwash (A) where group A1 patients will use chlorhexidine mouthwash as control group while group A2 patients will use chlorhexidine with propolis and clove oil mouthwash as intervention group with 32 patients in each group. Each group will be further divided into two groups according to times of application (T) where T1 represents patients using the mouthwash once daily for one week every month for 6 months and T2 where patients will use the mouthwash twice daily for one week every month for 6 months with 16 patients in each subgroup.

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients should be over 18 years of age.
• Patients should be with high caries risk assessment.

Exclusion criteria

• Patients with a compromised medical history.
• Severe or active periodontal disease.
• Patients with a diseased salivary gland
• History of allergies or other adverse reactions to chlorhexidine, propolis, bee stings, or clove
• Patients on any antibiotics during the past month

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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64 participants in 4 patient groups

Chlorhexidine Once Daily

Active Comparator group

Description:

Chlorhexidine HCL 0.12% mouthwash to be used once daily for one week each month for six months

Treatment:

Other: Chlorhexidine mouthwash

Chlorhexidine Twice Daily

Active Comparator group

Description:

Chlorhexidine HCL 0.12% mouthwash to be used twice daily for one week each month for six months

Treatment:

Other: Chlorhexidine mouthwash

Propolis Once Daily

Experimental group

Description:

Chlorhexidine Gluconate 0.12% with Propolis 1% and Clove Oil 1% mouthwash to be used once daily for one week each month for six months

Treatment:

Other: Chlorhexidine, Propolis and Clove Oil mouthwash

Propolis Twice Daily

Experimental group

Description:

Chlorhexidine Gluconate 0.12% with Propolis 1% and Clove Oil 1% mouthwash to be used twice daily for one week each month for six months

Treatment:

Other: Chlorhexidine, Propolis and Clove Oil mouthwash