Using a Novel Functional MRI Technique to Evaluate for Neurotoxicity

Memorial Sloan Kettering Cancer Center (MSK)

Status: Completed

Conditions: Central Nervous System Lymphoma

Treatments: Other: Self Reported Quality of Life Questionnaire; Other: Motor Speed Test; Diagnostic Test: Resting State fMRI (rsfMRI); Other: Auditory Attention and Executive Functions Test; Other: Memory Test

Study type: Observational

Funder types: Other

Identifiers

NCT03342586

17-403

Details and patient eligibility

About

The purpose of this study is to test resting state functional Magnetic Resonance Imaging (rsfMRI) scans to see if rsfMRI scans are better than the standard task based fMRI scans at diagnosing or monitoring central nervous system lymphoma.

Enrollment: 14 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Immunocompetent patients with newly diagnosed or recurrent non-Hodgkins lymphoma involving the brain (primary or secondary), as demonstrated by MRI and histologic confirmation either by positive CSF cytology for lymphoma or a monoclonal lymphocyte population defined by cell surface markers, vitreous or uvea biopsy or brain biopsy
• Age 18-80 years
• Treatment plan for HDC-ASCT
• Fluent in English
• Patients who in the judgment of the investigators and/or consenting professional, are able to understand the purpose of the study and provide informed consent will be included.

Exclusion criteria

• Claustrophobia
• Any contraindication to the use of contrast and/or general guidelines for MR imaging as per standard Department of Radiology imaging guidelines
• Unable to cooperate for MRI

Trial design

14 participants in 1 patient group

Central Nervous System Lymphoma

Description:

Participants will have non-Hodgkins lymphoma involving the brain (primary or secondary)

Treatment:

Other: Memory Test

Other: Motor Speed Test

Other: Auditory Attention and Executive Functions Test

Diagnostic Test: Resting State fMRI (rsfMRI)

Other: Self Reported Quality of Life Questionnaire