Using a Telemedicine Approach in a Genome-wide Association Study of Atopic Dermatitis - Searching for Novel Biomarkers in Clinically Relevant Phenotypes

Studies&Me

Status

Withdrawn

Conditions

Atopic Dermatitis

DNA

Eczema

Treatments

Behavioral: Information reports

Behavioral: DNA reports

Study type

Observational

Funder types

Other

Industry

Identifiers

NCT04965233

H-19020696

Details and patient eligibility

About

Atopic eczema is a common skin disorder affecting at least 2-3% of the western population. Atopic eczema cannot be cured and therefore treatment aims to alleviate the symptoms of the disease. Today, many different medical treatments are available: from mild hormone creams to harsh systemic treatments. The treatment chosen depends in part on the severity of the eczema and on the treatment response of the individual. This practice may mean that some people with eczema undergo unnecessary treatment courses with associated side effects. We know today that eczema has a hereditary component, and different areas have been identified in the hereditary material that appear to play a role. Although it is thought that variations in specific areas of the inheritance material may influence how eczema is expressed in the individual, the significance of these variations is far from clarified. The investigators want to increase the knowledge about atopic eczema, about the disease and how in the future we can organize the treatment of eczema based on knowledge of our genetic material. In this study, the investigators want to elucidate whether there is a correlation between specific variations in the genetic material and how the eczema is clinically expressed. In addition, the investigators want to assess whether reports with specific information about the individual's genetic material in relation to his or her lifestyle can help retain participants in research projects.

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Informed consent has been signed
18 years or older
Resident in the USA or Denmark
AD meeting the UK Diagnostic Criteria for Atopic Dermatitis
At least one visible AD lesion at the time of recruitment (as confirmed remotely through photo upload in screening)
Smartphone user with daily access to internet (WIFI or 3G/4G)
Willing to donate a DNA sample
Confirmed intention to comply with study protocol procedures

Exclusion criteria

Female subjects that are pregnant (or plan to become so during the study period) or lactating
Active dermatological condition that may confound the diagnosis of AD and/or the assessment of disease activity
Unable to speak or understand English or Danish
Overlap with participation in interventional trials
No visible AD at time of screening
Any other reasons that in the investigator's opinion could:
Impede a subject's ability to complete the study period
Influence the objectivity or quality of the findings of the study