Using Breath Metabolites to Determine Specific Virus Infection in Asthmatic Patients

University of California (UC) Davis

Status: Completed

Conditions: Upper Respiratory Tract Infections, Asthma, Exhaled Breath

Treatments: Diagnostic Test: Exhaled breath condensate collection

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03089970

1K23HL127185-01A1 (U.S. NIH Grant/Contract)

637013

Details and patient eligibility

About

Respiratory virus infections cause a majority of asthma exacerbations in the fall to spring months. Current diagnostic platforms for respiratory viruses have limitations including cost, availability, and invasiveness. The use of noninvasive breath collection to analyze breath metabolites may be used to differentiate virus-infected asthmatics from other causes of acute asthma exacerbations.

Enrollment: 19 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asthma, Age ≥12, Symptoms/signs of an early asthma exacerbation, Ability to provide exhaled breath condensate (EBC) x15 min, Body mass index (BMI) ≥18

Exclusion criteria

• Chronic lung diseases other than asthma (e.g., chronic obstructive pulmonary disease [COPD], lung cancer, fibrotic lung disease, etc.), Smoking in the past 7 days, Eating or non-clear liquids <4 hrs prior to EBC collection, Pregnancy

Trial design

19 participants in 3 patient groups

Healthy asthma

Description:

Asthmatic patients not with an exacerbation, i.e., stable asthmatics

Treatment:

Diagnostic Test: Exhaled breath condensate collection

Rhinovirus-infected asthmatics

Description:

Asthmatics with an exacerbation and associated rhinovirus infection

Treatment:

Diagnostic Test: Exhaled breath condensate collection

Influenza A-infected asthmatics

Description:

Asthmatics with an exacerbation and associated influenza A infection

Treatment:

Diagnostic Test: Exhaled breath condensate collection