Using Dexamethasone After Uvulopalatopharyngoplasty

University of Oklahoma (OU)

Status and phase: Completed; Phase 1

Conditions: Pain

Treatments: Drug: Placebo; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT00584168

UPPP Study, IRB # 12098 (Other Identifier)

Dexamethasone, UPPP - Houck

Details and patient eligibility

About

This study looks at lessening the pain after a Uvulopalatopharyngoplasty (UPPP) surgery by using Dexamethasone (a corticosteroid).

Full description

The study was designed because patients have a lot of pain after they have a UPPP. Certain drugs called steroids may lessen the pain associated from this surgery. This study uses Dexamethasone (a corticosteroid), to see if it will help reduce pain, decrease the amount of time until the patient can begin to eat or return to normal activity, or increase their satisfaction with pain management. In this study the patients will be randomized (computer chosen) to receive either the study drug (dexamethasone), or a placebo. The patient will start the day before surgery with a single pill. They will then receive the dexamethasone or a placebo twice daily for the next four days and then once daily for the next two days for a total of seven days. Afterward, they will be asked to complete a questionnaire. The five questions ask patients to access the amount of pain they have, how much of their normal diet or activity they have returned to, and how much pain medication they have taken. At the next follow-up visit they will be asked to complete another questionaire (9 questions) about the patient's satisfaction with pain management.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Candidates scheduled for UPPP surgery.
• Able to take steroids

Exclusion criteria

• Those patients who unable to take steroids

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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15 participants in 2 patient groups, including a placebo group

2

Placebo Comparator group

Description:

Patient will receive a placebo.

Treatment:

Drug: Placebo

1

Experimental group

Description:

Patient will receive dexamethasone.

Treatment:

Drug: Dexamethasone