Memory Retrieval and Encoding Investigated by Neural Stimulation (MEMREINS)

University of Pennsylvania

Status: Active, not recruiting

Conditions: Epilepsy Intractable

Treatments: Device: Direct electrical stimulation

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04286776

5R01NS106611-05 (U.S. NIH Grant/Contract)

820553

1U01NS113198-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain states and behavioral measures.

Enrollment: 800 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Expected to undergo intracranial implantation and postoperative electroencephalographic monitoring as part of a standard clinical procedure for the treatment of pharmacologically resistant epilepsy
2. Age 18 or older

Exclusion criteria

1. Any physical or cognitive disability or illness that would limit their ability to perform cognitive tasks
2. Any medical condition that would, in the investigator's opinion, limit the subject's participation in the study.
3. Unable or unwilling to provide informed consent
4. MRI contraindications

Standard clinical care includes a pregnancy test for female patients prior to the surgical implantation of the electrodes. Pregnant women are not surgically implanted.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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800 participants in 1 patient group

Direct Electrical Stimulation

Experimental group

Description:

Stimulation will be applied concurrently with the task, if applicable, and stimulation trials will be interleaved with sham trials, where no stimulation is delivered.

Treatment:

Device: Direct electrical stimulation