Using Multimodal Prehabilitation to Improve Outcomes for Frail Patients Undergoing Resection of Colorectal Cancer

McGill University

Status: Completed

Conditions: Colorectal Neoplasms

Treatments: Behavioral: Relaxation Techniques; Behavioral: Physical Exercise Program; Dietary Supplement: Whey Protein Isolate Powder

Study type: Interventional

Funder types: Other

Identifiers

NCT02502760

15-131-MUHC

Details and patient eligibility

About

The purpose of this study is to determine if a program of physical activity, nutritional supplements and relaxation techniques is effective at decreasing post operative complications in frail colorectal cancer patients undergoing resection.

Enrollment: 120 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Colorectal cancer patient undergoing resection
• Frail or intermediately frail patients (Fried score 2 and above)

Exclusion criteria

• Unable to communicate in French or English
• Premorbid conditions contraindicating physical exercise (dementia, Parkinson Disease, previous stroke with paresis, taking carbidopa/levodopa, donepezil or antidepressants)

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

Prehabilitation

Experimental group

Description:

Immediately after randomization and until surgery, patients in this arm will: 1. - Receive a personalized physical exercise program 2. - Receive nutritional counselling with Whey protein isolate powder 3. - Receive relaxation techniques

Treatment:

Behavioral: Relaxation Techniques

Dietary Supplement: Whey Protein Isolate Powder

Behavioral: Physical Exercise Program

Rehabilitation

Active Comparator group

Description:

Patients in this arm will receive the same personalized physical exercise program, nutritional intervention and relaxation techniques as patients in the other arm but to be started after surgery.

Treatment:

Behavioral: Relaxation Techniques

Dietary Supplement: Whey Protein Isolate Powder

Behavioral: Physical Exercise Program