Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment

Centre Hospitalier de Saint-Denis

Status: Completed

Conditions: Alzheimer's Disease; Brain Atrophy; Neurodegenerative Diseases; Leukoaraiosis; Hippocampus; Cortical and Subcortical Atrophy; Magnetic Resonance Imaging

Study type: Observational

Funder types: Other

Identifiers

NCT06965816

0030_IMAGERIE

Details and patient eligibility

About

This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease. Researchers are focusing on the hippocampus, a part of the brain that shrinks in people with Alzheimer's. The study will also explore other brain changes that often happen alongside hippocampal shrinkage. By analyzing these brain images, the study hopes to find ways to diagnose Alzheimer's earlier and more accurately using advanced imaging techniques.

Enrollment: 85 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who underwent a brain MRI (3D T1 Bravo and Cube FLAIR sequences) between January 2018 and June 2022.
• Diagnosis of Alzheimer's disease (for the Alzheimer group).
• No neurological disease for control group participants.
• Complete clinical and biological assessments available.
• Quality imaging without motion artifacts.

Exclusion criteria

• Incomplete clinical or radiological data.
• Poor image quality (e.g., motion artifacts).
• Presence of other neurodegenerative or psychiatric disorders.

Trial design

85 participants in 2 patient groups

Alzheimer Group

Description:

Alzheimer's patients

Control Group

Description:

Unreached witnesses