Using of Bone Marrow Stem Cell Concentrate with Platelet Rich Fibrin and Bone Graft in Bone Reconstruction of Upper Jaw Bony Cystic Defects, Comparing with Platelet Rich Fibrin with Bone Graft
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About
Will the use of bone marrow stem cells with platelet rich fibrin enhance and accelerate the bone regeneration in the upper jaw cystic defects ?
Full description
Reconstruction of critical size bone defect in maxillofacial surgery is a great challenge, current practice of bone reconstruction still having problems like delay in bone regeneration (up to 12 months) and bone graft failure and low availability of autogenous bone graft.
last decade stem cells therapy gained great interest, in many studies Bone marrow stem cells showed promising result in bone regeneration enhancing .
Platelet Rich Fibrin PRF also capability of enhancing bone and tissue regeneration by releasing of certain protein molecules call growth factors that initiate sequential biological events resulting in stem cells migration into the site of bone defect and differentiation to bone formation cells (osteoblast cells ).
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Age range 18-50 years
- Patients with a critical size maxillary cyst. (>3 cm)
- Patients that free of any significant medical conditions that could affect healing or outcomes.
Exclusion criteria
- Patients with large jaw cyst that endanger vital structures
- Patients with significant medical condition
- age under 18 years
Trial design
Primary purpose
Allocation
Interventional model
Masking
22 participants in 2 patient groups
Trial contacts and locations
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Central trial contact
Tareq El-Ghareeb, Professor; Motea Abdulsalm Sanad, PHD
Data sourced from clinicaltrials.gov
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