Using Open Contest and Neuro-influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men

Johns Hopkins Bloomberg School of Public Health

Status: Completed

Conditions: HIV/AIDS

Treatments: Behavioral: PrEP campaign messages developed via open contest; Behavioral: PrEP campaign messages developed via social marketing approach

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04166851

00008650

Details and patient eligibility

About

The aim of this study is to examine the utility of neuroimaging technique to evaluate pre-exposure prophylaxis (PrEP) promotion messages for men who have sex with men (MSM) at risk of HIV in Baltimore.

Full description

This study will examine the utility of neuroimaging technique to evaluate PrEP promotion messages for MSM at risk of HIV in Baltimore. The investigators hypothesize that participants viewing top messages developed via open contests will show higher brain activation in the Medial Prefrontal Cortex (MPFC) regions than those viewing messages developed by a social marketing approach. The investigators further hypothesize brain activation in the MPFC regions is significantly more correlated with PrEP behavioral intention, initiation, and action than self-reported message effectiveness.

Enrollment: 23 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years and older
• Biological male sex at birth
• Sexually active with men in the past 6 months
• Never taken PrEP
• HIV negative
• Reside in Baltimore City or surrounding counties
• Meet one of the criteria for being an appropriate PrEP candidate (i.e. in a relationship with a partner not known to be HIV-negative; are in a nonmonogamous relationship; have had any condomless anal sex with a casual male partner regardless of status in the prior 6 months; or had a positive sexual transmitted infection (STI) diagnosis within the prior 6 months).

Exclusion criteria

• Participated in open contest

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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23 participants in 2 patient groups

Open contest messages

Experimental group

Description:

Participants will view the top PrEP-promotion messages developed via an open contest.

Treatment:

Behavioral: PrEP campaign messages developed via open contest

Social marketing messages

Active Comparator group

Description:

Participants will view the PrEP-promotion messages developed via social marketing.

Treatment:

Behavioral: PrEP campaign messages developed via social marketing approach