Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia

The University of Chicago

Status: Not yet enrolling

Conditions: Acute Lymphoblastic Leukemia

Treatments: Other: High Intensity; Other: Low Intensity Text Messaging; Other: No Text Messagings

Study type: Interventional

Funder types: Other

Identifiers

NCT06446661

IRB23-1519

Details and patient eligibility

About

The purpose of this section is to learn how text message reminders might help with regularly taking chemotherapy medications for Adolescents and Adults with Acute Lymphoblastic leukemia (ALL).

Full description

This study aims to compare adherence to oral mercaptopurine and methotrexate during the first 84-day cycle of maintenance therapy for adolescent and young adult patients with Acute Lymphoblastic Leukemia on pediatric-based regimens between those who receive the high intensity text message intervention and those who receive standard-of-care. It is believed that high-intensity text messages will increase patient adherence within cycle 1.

Enrollment: 38 estimated patients

Sex: All

Ages: 15 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age of 15-39 years-old at the time of initial ALL diagnosis
• Diagnosed with ALL
• Currently receiving treatment with pediatric-based regimen that includes maintenance with mercaptopurine and methotrexate (e.g., CALGB 10403). Study participation begins with the start of maintenance, so enrollment occurs prior to the start of maintenance.

Exclusion criteria

• Patient or caregiver who would receive text message reminders does not have a cell phone that receives text messages
• Patient does not wish to participate
• Text messages will be crafted in the patient's preferred language for medical communication, so English fluency is not an enrollment requirement.

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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38 participants in 2 patient groups

High Intensity

Active Comparator group

Description:

Receives high-intensity text messaging for 2 cycles of treatment

Treatment:

Other: High Intensity

Low Intensity

Active Comparator group

Description:

Receives no texts for 1st cycle and low-intensity texts for 2nd cycle

Treatment:

Other: No Text Messagings

Other: Low Intensity Text Messaging