Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression (OBESITA'&PCa)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Prostate Neoplasm; Prostate Adenocarcinoma; Prostatic Neoplasm; Obesity; Prostate Cancer

Treatments: Other: observational study

Study type: Observational

Funder types: Other

Identifiers

NCT06292897

3312

Details and patient eligibility

About

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI > 27.5) and non-severely overweight/normoweight (BMI < 27.5) patients affected by prostate carcinoma.

ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.

iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Enrollment: 25 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• affected by prostate cancer

Exclusion criteria

Trial design

25 participants in 2 patient groups

obese individuals [Body Mass Index (BMI) > 30 affected by prostate cancer

Treatment:

Other: observational study

normal-weight individuals [18 < BMI < 25] affected by prostate cancer