Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis

University of California San Diego

Status: Completed

Conditions: Osteoarthritis

Treatments: Drug: triamcinolone acetonide; Drug: saline

Study type: Interventional

Funder types: Other

Identifiers

NCT00746889

IRB 051420

Details and patient eligibility

About

A study using characteristics on ultrasound to predict response to intraarticular steroid injections in patients with knee osteoarthritis. The hypothesis is that patients with inflammation on ultrasound will have a better response to corticosteroid injections compared to patients without inflammation.

Enrollment: 79 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• knee pain
• diagnosis of osteoarthritis in affected knee

Exclusion criteria

• intraarticular corticosteroids in affected knee within past three months
• primary inflammatory connective tissue disease (ie rheumatoid arthritis)
• currently taking oral corticosteroids

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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79 participants in 2 patient groups, including a placebo group

Corticosteroid Injection

Active Comparator group

Description:

40 mg of intraarticular triamcinolone acetonide

Treatment:

Drug: triamcinolone acetonide

Placebo Injection

Placebo Comparator group

Description:

Intraarticular injection of 0.9% saline

Treatment:

Drug: saline