Uterine Flushing With Human Chorionic Gonadotrophin and Unexplained Infertility

Ahmed Walid Anwar Murad

Status: Completed

Conditions: Unexplained Infertility

Treatments: Procedure: Vaginal flushing with 10 ml normal saline; Procedure: HCG Uterine flushing; Procedure: IUI

Study type: Interventional

Funder types: Other

Identifiers

NCT03461601

18144

Details and patient eligibility

About

A prospective randomized study included 210 women with Unexplained infertility subjected to combined ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.

Full description

A prospective randomized study included 210 patients with Unexplained infertility subjected to coupled ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.

Enrollment: 210 patients

Sex: Female

Ages: 18 to 37 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Unexplained infertility (UI)

Exclusion criteria

• body mass index (BMI) ≥35 kg/m2,
• Follicle Stimulating Hormone >10 International Unit /Litter in early follicular phase,
• diagnosed cause of infertility, menstrual cycle irregularity,
• ovarian cysts,
• sever cervical stenosis,
• former IUI,
• ongoing pregnancy and
• renal or hepatic diseases were all the exclusion criteria.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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210 participants in 2 patient groups, including a placebo group

HCG uterine flushing group

Active Comparator group

Description:

Uterine flushing was done one day before Intrauterine insemination (IUI) with HCG (500 IU) in 10 ml of saline followed by Intrauterine insemination (IUI).

Treatment:

Procedure: HCG Uterine flushing

Procedure: IUI

IUI alone group

Placebo Comparator group

Description:

Intrauterine insemination alone plus vaginal flushing with 10 ml normal saline

Treatment:

Procedure: Vaginal flushing with 10 ml normal saline

Procedure: IUI