Uterine Microbiome in Women with Repeated Implantation Failure and Normal Fertile Women

Ghent University Hospital (UZ)

Status: Completed

Conditions: Repeated Implantation Failure; Normal Fertile

Treatments: Other: Vaginal swab + endometrial biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT03405883

BE670201733152

Details and patient eligibility

About

Characterization of the uterine microbiome in women with repeated implantation failure as well as in normal fertile women.

Full description

In the midluteal phase of the cycle, a vaginal swab and endometrial biopsy will be obtained.

Enrollment: 13 patients

Sex: Female

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women between their 18th and 40th birthdays (max 39 years and 364 days at the day of signing the informed consent)
• Able to understand, read and speak Dutch and hence to provide written and oral informed consent
• Negative serological tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), Rapid plasma reagin (RPR) for syphilis

Exclusion criteria

• Hormonal contraception in current cycle
• Presence of intra-uterine device
• Antibiotic treatment in the current cycle

Trial design

13 participants in 2 patient groups

RIF (women with repeated implantation failure)

Description:

Transfer of at least 5 good quality embryos in IVF or ICSI cycles, without achieving pregnancy

Treatment:

Other: Vaginal swab + endometrial biopsy

NF (normal fertile women)

Description:

Spontaneous conception or conception after max 9 IUI cycles

Treatment:

Other: Vaginal swab + endometrial biopsy