Uterus Transplantation From a Multi-organ Donor

Ghent University Hospital (UZ)

Status: Enrolling

Conditions: Mayer Rokitansky Kuster Hauser Syndrome; Infertility, Female

Treatments: Procedure: uterus transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT03252795

EC/2016/0731

Details and patient eligibility

About

Uterus transplantation: screening, in vitro fertilization [IVF] treatment to be able to freeze embryos, uterus transplantation, pregnancy and afterwards removal of the uterus.

Enrollment: 20 estimated patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female with Maier-Rokitansky-Kuster-Hauser syndrome
• Mucosal neovagina of at least 7 cm
• In a stable relationship for at least 1 year
• Child wish
• Good renal function (and presence of both kidneys)
• Psychologically stable and compliant
• At least 8 frozen embryos after IVF/intracytoplasmic sperm injection [ICSI]
• Living in Belgium and a good health insurance
• Willing and able to provide informed consent

Exclusion criteria

• Major pelvic surgery
• Major chronic illnesses
• Other risk factors or malignancies
• BMI > 30

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Uterus transplantation

Experimental group

Treatment:

Procedure: uterus transplantation