Utility of CC7 Transfer in Stroke Subtypes

Dartmouth Health

Status: Enrolling

Conditions: Stroke Hemorrhagic; Stroke, Ischemic; Spastic Hemiparesis

Treatments: Procedure: Contralateral C7 root transfer for the treatment of spastic hemiparesis.

Study type: Interventional

Funder types: Other

Identifiers

NCT06001736

STUDY02000583

Details and patient eligibility

About

The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.

Full description

Spastic limb paresis after stroke is a cause of long-term disability and reduction is quality of life, with loss of hand dexterity being especially prohibitive. In the recovery phase after initial injury, neural reorganization occurs and has been observed in both ipsilateral and contralateral hemispheres. Previous studies have identified contralesional (opposite to the side of the injury), in other words, ipsilateral, activation in the recovery of paretic hand function. However, this pathway of recovery is limited due to sparse connections between the ipsilateral hemisphere and the affected arm/hand. By establishing an anatomic connection between the ipsilateral hemisphere and the paretic arm with contralateral nerve transfer, compensatory capacity of the ipsilateral hemisphere is facilitated. This cross neck C7-C7 root transfer is an established procedure for the treatment of brachial plexus injuries and recently, for the treatment of spastic arm paresis in those with cerebral injury.

Enrollment: 95 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.

Exclusion criteria

• pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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95 participants in 1 patient group

Contralateral C7 root transfer for the treatment of spastic hemiparesis.

Experimental group

Description:

The C7 nerve root transfer will occur to the patients on this arm.

Treatment:

Procedure: Contralateral C7 root transfer for the treatment of spastic hemiparesis.