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Utilization of Donor Whole Blood for Blood Transfusion in Deceased Donor Liver Transplantation

Vanderbilt University Medical Center logo

Vanderbilt University Medical Center

Status and phase

Withdrawn
Early Phase 1

Conditions

Transfusion Related Complication
Liver Transplant

Treatments

Biological: Banked Blood
Biological: Donor Blood

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

We will study 40 matched patients. 20 patients will receive leukoreduced whole blood from the solid organ donor. These 20 patients will be compared to 20 historical matched controls with regards to allogenic blood product usage and other physiologic markers

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

    • Recipients 18 years or older.
  • Deceased donor whole graft liver transplant recipients undergoing liver transplant starting 07/01/2020 and onwards at VUMC.
  • ABO-matched recipient and donor.
  • Donor Hb level >/= 8 g/dL
  • Recipients with negative ABO antibody screen

Exclusion criteria

    • Pediatric recipient.
  • HBS Antigen+ donors
  • HCV NAT+ donors
  • Donors of A2 blood type
  • Donors on oral anticoagulants (except for aspirin) over the past 3 days before organ procurement

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

0 participants in 2 patient groups

Donor Blood
Experimental group
Description:
Between 2-4 units of donor leukoreduced whole blood (each unit will contain up to 350mL) transfused as needed in Liver transplantation participants
Treatment:
Biological: Donor Blood
Banked Blood
Active Comparator group
Description:
Standard of Care - Up to 350mL Allogenic banked component blood transfusion in a 1:1:1 manner (packed red blood cells : plasma : platelets) transfused as needed in Liver transplantation participants
Treatment:
Biological: Banked Blood

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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