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Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients (EGFR Lung Canc)

O

Our Lady of the Lake Hospital

Status

Begins enrollment in 1 month

Conditions

EGFR Exon 19 Deletion Mutation
Lung Cancer - Non Small Cell

Treatments

Other: Gene sequencing
Other: blood draw

Study type

Interventional

Funder types

Other

Identifiers

NCT06659458
LSUHSCIRB_7781

Details and patient eligibility

About

EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.

Enrollment

20 estimated patients

Sex

Female

Ages

18 to 100 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 18-100 years old
  • Biologically born female
  • Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group)
  • No cancer diagnosis (Arm 2-health control)

Exclusion criteria

  • less than 18 years of age
  • Biologically born male
  • Incarcerated at the time of participation

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

20 participants in 2 patient groups

EGFR Positive Lung Cancer
Experimental group
Description:
Subjects diagnosed with EGFR positive lung cancer
Treatment:
Other: Gene sequencing
Other: blood draw
Healthy Subjects
Experimental group
Description:
Subjects who do not have a cancer diagnosis
Treatment:
Other: Gene sequencing
Other: blood draw

Trial contacts and locations

1

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Central trial contact

Christine LeBoeuf, DNP; Cynthia Knox, MBA

Data sourced from clinicaltrials.gov

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